Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma

被引：30

作者：

Chiu, Kin ^{[1
,2
]}

Yeung, Sze-Chun ^{[1
]}

So, Kwok-Fai ^{[1
,2
,3
]}

Chang, Raymond Chuen-Chung ^{[1
,2
,3
]}

机构：

[1] Univ Hong Kong, Dept Anat, Lab Neurodegenerat Dis, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Hong Kong, Peoples R China

[3] Univ Hong Kong, Li Ka Shing Fac Med, Res Ctr Heart Brain Hormone & Healthy Aging, Hong Kong, Hong Kong, Peoples R China

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2010年 / 7卷 / 01期

关键词：

glaucoma; IGF-1; MCP-1/CCL2; microglia; neuroprotection; RETINAL GANGLION-CELLS; GROWTH-FACTOR-I; IGF-I; OCULAR HYPERTENSION; ACTIVATED MICROGLIA; NERVE INJURY; RAT-BRAIN; NEUROTOXICITY; EXPRESSION; RESPONSES;

D O I：

10.1038/cmi.2009.110

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Monocyte chemoattractant protein-1 (MCP-1)/CCL2 is a C-C chemokine involved in the activation and recruitment of monocytic cells to injury sites. MCP-1/CCL2 can induce either neuroprotection or neurodestruction in vitro, depending on the experimental model. We aim to use MCP-1/CCL2 as an experimental tool to investigate the morphological changes of microglia when loss of healthy retinal ganglion cells (RGCs) is exacerbated or attenuated in an experimental glaucoma model. While a high concentration (1000 ng) of MCP-1/CCL2 and lipopolysaccharide (LPS)-exacerbated RGC loss, 100 ng MCP-1/CCL2 provided neuroprotection towards RGC. Neuroprotective MCP-1/CCL2 (100 ng) also upregulated insulin-like growth factor-1 (IGF-1) immunoreactivity in the RGCs. The neuroprotective effect of MCP-1/CCL2 was not due to the massive infiltration of microglia/macrophages. Taken together, this is the first report showing that an appropriate amount of MCP-1/CCL2 can protect RGCs in experimental glaucoma. Cellular & Molecular Immunology (2010) 7, 61-68; doi:10.1038/cmi.2009.110

引用

页码：61 / 68

页数：8

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