Induction of UCP2 mRNA by thyroid hormones in rat heart

被引：85

作者：

Lanni, A

DeFelice, M

Lombardi, A

Moreno, M

Fleury, C

Ricquier, D

Goglia, F

机构：

[1] UNIV NAPLES FEDERICO II,DIPARTIMENTO FISIOL GEN & AMBIENTALE,I-80134 NAPLES,ITALY

[2] STN ZOOL A DOHRN,I-80121 NAPLES,ITALY

[3] UNIV MESSINA,FAC MED,IST PATOL GEN,MESSINA,ITALY

[4] UNIV SALERNO,FAC SCI,DIPARTIMENTO CHIM,I-84081 BARONISSI,SALERNO,ITALY

[5] CNRS,CTR RECH ENDOCRINOL MOL & DEV,F-92190 MEUDON,FRANCE

来源：

FEBS LETTERS | 1997年 / 418卷 / 1-2期

关键词：

uncoupling protein; thyroid hormone; heart; skeletal muscle; hypothyroidism;

D O I：

10.1016/S0014-5793(97)01375-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The possible regulation of the expression of uncoupling protein-2 (UCP2) mRNA by thyroid hormones in different tissues was examined in rats, Triiodothyronine (T-3) was found to produce an organ-specific enhancement of UCP2 expression in rat tissues. The effect of T-3 was markedly observed in heart, whereas a moderate effect was seen in skeletal muscle and no effect in kidney or liver, These results suggest that UCP2 is a protein that may be involved in the nuclear-mediated effect of T-3 on resting metabolic rate in the rat. (C) 1997 Federation of European Biochemical Societies.

引用

页码：171 / 174

页数：4

共 24 条

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