Why Vitamin E Therapy Fails for Treatment of Alzheimer's Disease

被引：45

作者：

Brewer, Gregory J. ^{[1
,2
,3
]}

机构：

[1] So Illinois Univ, Sch Med, Dept Neurol, Springfield, IL 62794 USA

[2] So Illinois Univ, Sch Med, Dept Med Microbiol, Springfield, IL 62794 USA

[3] So Illinois Univ, Sch Med, Dept Immunol & Cell Biol, Springfield, IL 62794 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2010年 / 19卷 / 01期

关键词：

OXIDATIVE STRESS; REDOX STATUS; SUPPLEMENTATION; PREVENTION; BRAIN;

D O I：

10.3233/JAD-2010-1238

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

引用

页码：27 / 30

页数：4

共 29 条

[11] Critical age-related loss of cofactors of neuron cytochrome C oxidase reversed by estrogen [J].

Jones, Torrie T. ;

Brewer, Gregory J. .

EXPERIMENTAL NEUROLOGY, 2009, 215 (02) :212-219

[12] Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model [J].

Joseph, JA ;

Denisova, NA ;

Arendash, G ;

Gordon, M ;

Diamond, D ;

Shukitt-Hale, B ;

Morgan, D .

NUTRITIONAL NEUROSCIENCE, 2003, 6 (03) :153-162

[13]

Kamsler A, 2003, J NEUROSCI, V23, P269

[14] Vitamin E Paradox in Alzheimer's Disease: It Does Not Prevent Loss of Cognition and May Even Be Detrimental [J].

Lloret, Ana ;

Badia, Mari-Carmen ;

Mora, Nancy J. ;

Pallardo, Federico V. ;

Alonso, Maria-Dolores ;

Vina, Jose .

JOURNAL OF ALZHEIMERS DISEASE, 2009, 17 (01) :143-149

[15] Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease [J].

Markesbery, WR ;

Lovell, MA .

NEUROBIOLOGY OF AGING, 1998, 19 (01) :33-36

[16] Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study [J].

Milgram, NW ;

Head, E ;

Zicker, SC ;

Ikeda-Douglas, CJ ;

Murphey, H ;

Muggenburg, B ;

Siwak, C ;

Tapp, D ;

Cotman, CW .

NEUROBIOLOGY OF AGING, 2005, 26 (01) :77-90

[17] Meta-analysis: High-dosage vitamin E supplementation may increase all-cause mortality [J].

Miller, ER ;

Pastor-Barriuso, R ;

Dalal, D ;

Riemersma, RA ;

Appel, LJ ;

Guallar, E .

ANNALS OF INTERNAL MEDICINE, 2005, 142 (01) :37-46

[18]

Nunomura A, 1999, J NEUROSCI, V19, P1959

[19] Age-related decreases in NAD(P)H and glutathione cause redox declines before ATP loss during glutamate treatment of hippocampal neurons [J].

Parihar, Mordhwaj S. ;

Kunz, Elizabeth A. ;

Brewer, Gregory J. .

JOURNAL OF NEUROSCIENCE RESEARCH, 2008, 86 (10) :2339-2352

[20] Mitoenergetic failure in Alzheimer disease [J].

Parihar, Mordhwaj S. ;

Brewer, Gregory J. .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2007, 292 (01) :C8-C23

← 1 2 3 →