How the MHC selects Th1/Th2 immunity

被引：140

作者：

Murray, JS ^{[1
]}

机构：

[1] Univ Kansas, Dept Microbiol, Lawrence, KS 66045 USA

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 04期

关键词：

D O I：

10.1016/S0167-5699(97)01237-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

While the effects of cytokines on T helper 1 (Th1)/Th2 differentiation are well documented, it is less clear why a dichotomy of effector cytokine production would initiate from antigen-specific lymphocytes. Nevertheless, in defined experimental systems, the interaction between T-cell receptor (TCR), peptide and major histocompatibility complex (MHC) can determine Th1/Th2 dominance. Here, Joseph Murray discusses how TCR affinity and ligand density might interface with innate forces in the selection of CD4(+) T-cell functions.

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页码：157 / 163

页数：7

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