Signaling in myxobacteria

被引:167
作者
Kaiser, D [1 ]
机构
[1] Stanford Univ, Dept Biochem, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Dev Biol, Stanford, CA 94305 USA
关键词
microbial development; morphogenesis; sporulation; gliding motility; type IV pili;
D O I
10.1146/annurev.micro.58.030603.123620
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Myxobacteria use soluble and cell-contact signals during their starvation-induced formation of fruiting bodies. These signals coordinate developmental gene expression with the cell movements that build fruiting bodies. Early in development, the quorum-sensing A-signal in Myxococcus xanthus helps to assess starvation and induce the first stage of aggregation. Later, the morphogenetic C-signal helps to pattern cell movement and shape the fruiting body. C-signal is a 17-kDa cell surface protein that signals by contact between the ends of two cells. The number of C-signal molecules per cell rises 100-fold from the beginning of fruiting body development to the end, when spores are formed. Traveling waves, streams, and sporulation have increasing thresholds for C-signal activity, and this progression ensures that spores form inside fruiting bodies.
引用
收藏
页码:75 / 98
页数:26
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