Genetics of rheumatoid arthritis susceptibility, severity, and treatment response

被引：110

作者：

Viatte, Sebastien ^{[1
]}

Barton, Anne ^{[1
,2
]}

机构：

[1] Univ Manchester, Arthrit Res UK Ctr Genet & Genom, Ctr Musculoskeletal Res, Fac Biol Med & Hlth,Manchester Acad Hlth Sci Ctr, Oxford Rd, Manchester M13 9PT, Lancs, England

[2] Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, NIHR Manchester Musculoskeletal Biomed Res Unit, Grafton St, Manchester M13 9WL, Lancs, England

来源：

SEMINARS IN IMMUNOPATHOLOGY | 2017年 / 39卷 / 04期

基金：

英国医学研究理事会;

关键词：

GENOME-WIDE ASSOCIATION; SINGLE-NUCLEOTIDE POLYMORPHISM; JUVENILE IDIOPATHIC ARTHRITIS; SHARED EPITOPE HYPOTHESIS; JOINT DESTRUCTION; RADIOGRAPHIC SEVERITY; DISEASE-ACTIVITY; LARGE PROPORTION; RISK VARIANTS; PROGRESSION;

D O I：

10.1007/s00281-017-0630-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

A decade after the first genome-wide association study in rheumatoid arthritis (RA), a plethora of genetic association studies have been published on RA and its clinical or serological subtypes. We review the major milestones in the study of the genetic architecture of RA susceptibility, severity, and response to treatment. We set the scientific context necessary for non-geneticists to understand the potential clinical applications of human genetics and its significance for a stratified approach to the management of RA in the future.

引用

页码：395 / 408

页数：14

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