Polystyrene-anchored Cinchona ammonium salts:: Easily recoverable phase-transfer catalysts for the asymmetric synthesis of α-amino acids

被引：58

作者：

Chinchilla, R

Mazón, P

Nájera, C

机构：

[1] Univ Alicante, Dept Quim Organ, E-03080 Alicante, Spain

[2] Univ Alicante, ISO, E-03080 Alicante, Spain

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2004年 / 346卷 / 9-10期

关键词：

alkylation; amino acids; ammonium salts; asymmetric synthesis; C-C bond formation; organic catalysis; phase-transfer catalysis;

D O I：

10.1002/adsc.200404093

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Cinchonidine, epicinchonidine, cinchonine or quinine have been N-anchored to cross-linked polystyrene (Merrifield resin) or grafted polystyrene (Syn-Phase(TM) Lanterns) affording polymer-supported chiral ammonium salts which are employed as phase-transfer catalysts in the asymmetric alkylation of N-(diphenylmethylene)glycine esters. These new polymeric catalysts can be easily recovered after the reaction by simple filtration and reused.

引用

页码：1186 / 1194

页数：9

共 111 条

[31] A rational approach to catalytic enantioselective enolate alkylation using a structurally rigidified and defined chiral quaternary ammonium salt under phase transfer conditions [J].