Effect of DL-α-lipoic acid on neural antioxidants in aged rats

被引：43

作者：

Arivazhagan, P ^{[1
]}

Panneerselvam, C ^{[1
]}

机构：

[1] Univ Madras, Dr AL Mudaliar Post Grad Inst Basic Med Sci, Dept Med Biochem, Chennai 600113, India

来源：

PHARMACOLOGICAL RESEARCH | 2000年 / 42卷 / 03期

关键词：

lipoic acid; antioxidants; lipid peroxide and aged rats;

D O I：

10.1006/phrs.2000.0679

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of DL-alpha-lipoic acid on lipid peroxidation and antioxidants were evaluated in various blain regions of young and aged rats. In aged rats, the levels of ascorbic acid, alpha-tocopherol and glutathione were low whereas the lipid peroxidation rate, as revealed by malonaldehyde content, was found to be high. Lipoic acid, an antioxidant, was administered intraperitoneally (100 mg/kg body weight/day) for 7 and 14 days. Lipoate-administered aged rats brought about reduction in lipid peroxidation and elevation in the levels of antioxidants. The modulatory effect of lipoate in decreasing age-associated alterations observed in our study proves its role as a potent antioxidant in the brain of aged rats. (C) 2000 Academic Press.

引用

页码：219 / 222

页数：4

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