Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery

被引：715

作者：

Bromberg, LE ^{[1
]}

Ron, ES ^{[1
]}

机构：

[1] Sensei Pharmaceut, Lexington, MA 02173 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1998年 / 31卷 / 03期

关键词：

pluronic-g-poly(acrylic acid) conjugates; pluronic surfactants; poly(ethylene oxide) and poly(propylene oxide) triblock copolymers; protein and peptide delivery; temperature-sensitive polymers;

D O I：

10.1016/S0169-409X(97)00121-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The explosive development of protein and peptide drugs has ushered in a great need for effective delivery systems for such drugs. Two decades of studies of protein delivery from polymeric systems has revealed the great potential of gels that respond to environmental stimuli, such as temperature. Protein and peptide release can be engineered to occur in a pulsatile mode. The mechanism of this release is greatly affected by polymer design. 'Intelligent' amphiphilic copolymers emerge as a novel trend in the application of thermodynamically stable self-assembling lyophilic colloids to protein and peptide delivery. (C) 1998 Elsevier Science B.V.

引用

页码：197 / 221

页数：25

共 247 条

[41] BROMBERG LE, 1990, ZH FIZ KHIM+, V64, P1022
[42] BROMBERG LE, 1989, COLLOID J USSR+, V51, P477
[43] BROMBERG LE, 1991, J MEMBRANE SCI, V62, P117, DOI 10.1016/0376-7388(91)80056-C
[44] DETERGENT-ENABLED TRANSPORT OF PROTEINS AND NUCLEIC-ACIDS THROUGH HYDROPHOBIC SOLVENTS
BROMBERG, LE
KLIBANOV, AM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (01) : 143 - 147
[45] TRANSPORT OF PROTEINS DISSOLVED IN ORGANIC-SOLVENTS ACROSS BIOMIMETIC MEMBRANES
BROMBERG, LE
KLIBANOV, AM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (05) : 1262 - 1266
[46] BROMBERG LE, 1997, P POLYM MAT SCI ENG, V76, P273
[47] BROMBERG LE, 1987, SYNTHETIC POLYM MEMB, P397
[48] BROMBERG LE, 1997, POLYM PREPR, V38, P602
[49] BROMBERG LE, 1997, POLYM PREPR, V38, P626
[50] BROWN L, 1995, P AM CHEM SOC C FORM, P76

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