Tropheryma whipplei in Patients with Pneumonia

被引：87

作者：

Bousbia, Sabri ^{[1
]}

Papazian, Laurent ^{[1
,2
]}

Auffray, Jean-Pierre ^{[2
]}

Fenollar, Florence ^{[1
]}

Martin, Claude ^{[3
]}

Li, Wenjun ^{[1
]}

Chiche, Laurent ^{[2
]}

La Scola, Bernard ^{[1
]}

Raoult, Didier ^{[1
]}

机构：

[1] Fac Med Marseille, CNRS, IRD, F-13385 Marseille, France

[2] Hop Sud, Marseille, France

[3] Hop Nord Marseille, Marseille, France

来源：

EMERGING INFECTIOUS DISEASES | 2010年 / 16卷 / 02期

关键词：

VENTILATOR-ASSOCIATED PNEUMONIA; CYSTIC-FIBROSIS; WHIPPELII DNA; DISEASE; GENOME; IDENTIFICATION; BACILLUS; BACTERIUM; CULTURE; SALIVA;

D O I：

10.3201/eid1602.090610

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tropheryma whipplei is the etiologic pathogenic agent of Whipple disease (WD), characterized by various clinical signs, such as diarrhea, weight loss, lymphadenopathy, and polyarthritis. PCR-based methods for diagnosis of WD have been developed. T whipplei has been identified in saliva and stool samples from patients with WD and from healthy persons. T whipplei DNA has also been found in bronchoalveolar lavage (BAL) samples of a child with pneumonia. We detected DNA of T whipplei in 6 (3%) of 210 BAL samples collected in intensive care units by using 16S rDNA and specific quantitative PCR. We identified 4 novel genotypes of T whipplei. In 1 case, T whipplei was the only bacterium; in 4 others, it was associated with buccal flora. We suggest that T whipplei should be investigated as an etiologic agent of pneumonia.

引用

页码：258 / 263

页数：6

共 30 条

[21] Cultivation of the bacillus of Whipple's disease. [J].

Raoult, D ;

Birg, ML ;

La Scola, B ;

Fournier, PE ;

Enea, M ;

Lepidi, H ;

Roux, V ;

Piette, JC ;

Vandenesch, F ;

Vital-Durand, D ;

Marrie, TJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (09) :620-625

[22] Culture and immunological detection of Tropheryma whippelii from the duodenum of a patient with Whipple disease [J].

Raoult, D ;

La Scola, B ;

Lecocq, P ;

Lepidi, H ;

Fournier, PE .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (08) :1039-1043

[23] Tropheryma whipplei twist:: A human pathogenic Actinobacteria with a reduced genome [J].

Raoult, D ;

Ogata, H ;

Audic, S ;

Robert, C ;

Suhre, K ;

Drancourt, M ;

Claverie, JM .

GENOME RESEARCH, 2003, 13 (08) :1800-1809

[24] IDENTIFICATION OF THE UNCULTURED BACILLUS OF WHIPPLES DISEASE [J].

RELMAN, DA ;

SCHMIDT, TM ;

MACDERMOTT, RP ;

FALKOW, S .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (05) :293-301

[25] Genome-based design of a cell-free culture medium for Tropheryma whipplei [J].

Renesto, P ;

Crapoulet, N ;

Ogata, H ;

La Scola, B ;

Vestris, G ;

Claverie, JM ;

Raoult, D .

LANCET, 2003, 362 (9382) :447-449

[26] Whipple's disease: new aspects of pathogenesis and treatment [J].

Schneider, Thomas ;

Moos, Verena ;

Loddenkemper, Christoph ;

Marth, Thomas ;

Fenollar, Florence ;

Raoult, Didier .

LANCET INFECTIOUS DISEASES, 2008, 8 (03) :179-190

[27] Tropheryma whippelii DNA in saliva of healthy people [J].

Street, S ;

Donoghue, HD ;

Neild, GH .

LANCET, 1999, 354 (9185) :1178-1179

[28]

Whipple GH, 1907, B JOHNS HOPKINS HOSP, V18, P382

[29] PHYLOGENY OF THE WHIPPLES-DISEASE-ASSOCIATED BACTERIUM [J].

WILSON, KH ;

BLITCHINGTON, R ;

FROTHINGHAM, R ;

WILSON, JAP .

LANCET, 1991, 338 (8765) :474-475

[30]

YARDLEY JH, 1961, B JOHNS HOPKINS HOSP, V109, P80

← 1 2 3 →