Parallel synthesis of cyclic sugar amino acid/amino acid hybrid molecules

被引：64

作者：

van Well, RM ^{[1
]}

Overkleeft, HS ^{[1
]}

Overhand, M ^{[1
]}

Carstenen, EV ^{[1
]}

van der Marel, GA ^{[1
]}

van Boom, JH ^{[1
]}

机构：

[1] Leiden Univ, Gorlaeus Labs, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 48期

关键词：

sugar amino acid; host molecule; robot-assisted SPS; oxime linker;

D O I：

10.1016/S0040-4039(00)01693-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a furanoid sugar amino acid and its application in a parallel robot-assisted construction of cyclic sugar amino acid/amino acid hybrids as new potential host molecules is described. A cursory structural analysis by NMR revealed that one of the resulting cyclic hybrids (i.e. 2b) adopts a preferred conformation. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9331 / 9335

页数：5

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