The heteroyohimbine mayumbine binds with high affinity to rat brain benzodiazepine receptors in vitro

被引：8

作者：

Ai, J ^{[1
]}

Dekermendjian, K ^{[1
]}

Nielsen, M ^{[1
]}

Witt, MR ^{[1
]}

机构：

[1] Sct Hans Hosp, Dept Biochem, Res Inst Biol Psychiat, DK-4000 Roskilde, Denmark

来源：

NATURAL PRODUCT LETTERS | 1997年 / 11卷 / 01期

关键词：

mayumbine; CNS; GABA(A)/BZD receptors; in vitro-binding;

D O I：

10.1080/10575639708043760

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mayumbine, a naturally occurring heteroyohimbine, was isolated from Rauwolfia vomitoria extracts and shown to potently (IC50 = 76 +/- 3.5 nM) inhibit the in vitro binding of H-3-diazepam to the benzodiazepine sites within the rat GABA(A) receptor complex.

引用

页码：73 / 76

页数：4

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