DNA with hydrophobic base substitutes: A stable, zipperlike recognition motif based on interstrand-stacking interactions

被引：83

作者：

Brotschi, C ^{[1
]}

Leumann, CJ ^{[1
]}

机构：

[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 14期

关键词：

biaryls; bioorganic chemistry; DNA recognition; hydrophobic effect; nucleosides;

D O I：

10.1002/anie.200250516

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Back to basis: Short DNA duplexes can be packed with at least four hydrophobic, not-hydrogen-bonding biphenyl base pairs in the center of the sequence without compromising stability. Recognition of Bph occurrs by interstrand-stacking interactions as illustrated (X=biphenyl or bipyridyl). This new zipperlike recognition motif opens exciting possibilities for the introduction of new function into double-helical recognition systems based on the DNA backbone.

引用

页码：1655 / 1658

页数：4

共 37 条

[1] Structure of a copper-mediated base pair in DNA
Atwell, S
Meggers, E
Spraggon, G
Schultz, PG
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (49) : 12364 - 12367
[2] Stability and selectivity of unnatural DNA with five-membered-ring nucleobase analogues
Berger, M
Luzzi, SD
Henry, AA
Romesberg, FE
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (07) : 1222 - 1226
[3] Berger M, 2000, ANGEW CHEM INT EDIT, V39, P2940, DOI 10.1002/1521-3773(20000818)39:16<2940::AID-ANIE2940>3.0.CO
[4] 2-#
[5] BERGER M, 2000, ANGEW CHEM, V112, P3069
[6] Thermodynamic parameters for DNA sequences with dangling ends
Bommarito, S
Peyret, N
SantaLucia, J
[J]. NUCLEIC ACIDS RESEARCH, 2000, 28 (09) : 1929 - 1934
[7] Brotschi C, 2001, ANGEW CHEM INT EDIT, V40, P3012, DOI 10.1002/1521-3773(20010817)40:16<3012::AID-ANIE3012>3.0.CO
[8] 2-Y
[9] Cantor C.R., 1980, Biophysical Chemistry, V3, P1109
[10] Zipper-like Watson-Crick base-pairs
Chou, SH
Chin, KH
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2001, 312 (04) : 753 - 768

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