Synthesis and biological evaluation of nitric oxide-releasing derivatives of oleanolic acid as inhibitors of HepG2 cell apoptosis

被引:56
作者
Chen, Li
Zhang, Yihua
Kong, Xiangwen
Peng, Sixun
Tian, Jide
机构
[1] China Pharmaceut Univ, Ctr Drug Discovery, Nanjing 210009, Peoples R China
[2] China Pharmaceut Univ, Dept Phytochem, Nanjing 210038, Peoples R China
[3] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
关键词
oleanolic acid; nitrate; NO-donors; biological evaluation; apoptosis; HEPATOTOXICITY; METALLOTHIONEIN; PROTECTS; DONORS; DAMAGE; MICE;
D O I
10.1016/j.bmcl.2007.03.068
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A total of 106 nitric oxide-releasing derivatives of oleanolic acid were synthesized and their effects on the inhibition of anti-Fas-mediated HepG2 cell apoptosis were evaluated in vitro. Several compounds inhibited anti-Fas-mediated HepG2 cell apoptosis in a dose-dependent manner. Within this series of compounds, 8b is the most potent inhibitor. The development of new NO-releasing derivatives of oleanolic acid may aid in the design of NO-based medicines for the intervention of human liver inflammatory diseases. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2979 / 2982
页数:4
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