Synthesis and biological evaluation of nitric oxide-releasing derivatives of oleanolic acid as inhibitors of HepG2 cell apoptosis

被引：56

作者：

Chen, Li

Zhang, Yihua

Kong, Xiangwen

Peng, Sixun

Tian, Jide

机构：

[1] China Pharmaceut Univ, Ctr Drug Discovery, Nanjing 210009, Peoples R China

[2] China Pharmaceut Univ, Dept Phytochem, Nanjing 210038, Peoples R China

[3] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 11期

关键词：

oleanolic acid; nitrate; NO-donors; biological evaluation; apoptosis; HEPATOTOXICITY; METALLOTHIONEIN; PROTECTS; DONORS; DAMAGE; MICE;

D O I：

10.1016/j.bmcl.2007.03.068

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A total of 106 nitric oxide-releasing derivatives of oleanolic acid were synthesized and their effects on the inhibition of anti-Fas-mediated HepG2 cell apoptosis were evaluated in vitro. Several compounds inhibited anti-Fas-mediated HepG2 cell apoptosis in a dose-dependent manner. Within this series of compounds, 8b is the most potent inhibitor. The development of new NO-releasing derivatives of oleanolic acid may aid in the design of NO-based medicines for the intervention of human liver inflammatory diseases. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2979 / 2982

页数：4