Anticancer drugs from nature - natural products as a unique source of new microtubule-stabilizing agents

被引：220

作者：

Altmann, Karl-Heinz ^{[1
]}

Gertsch, Juerg ^{[1
]}

机构：

[1] ETH, Inst Pharmaceut Sci, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland

来源：

NATURAL PRODUCT REPORTS | 2007年 / 24卷 / 02期

关键词：

RING CLOSING METATHESIS; EPOTHILONE-B ANALOG; III BETA-TUBULIN; BIOSYNTHETIC GENE-CLUSTER; MEDIATED ALDOL REACTIONS; HUMAN TUMOR XENOGRAFTS; LARGE-SCALE SYNTHESIS; I CLINICAL-TRIAL; BIOLOGICAL EVALUATION; MARINE SPONGE;

D O I：

10.1039/b515619j

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review article provides an overview on the current state of research in the area of microtubule-stabilizing agents from natural sources, with a primary focus on the biochemistry, biology, and pharmacology associated with these compounds. A variety of natural products have been discovered over the last decade to inhibit human cancer cell proliferation through a taxol-like mechanism. These compounds represent a whole new range of structurally diverse lead structures for anticancer drug discovery.

引用

页码：327 / 357

页数：31

共 376 条

[1] Taxanes: Microtubule and Centrosome Targets, and Cell Cycle Dependent Mechanisms of Action [J].

Abal, M. ;

Andreu, J. M. ;

Barasoain, I. .

CURRENT CANCER DRUG TARGETS, 2003, 3 (03) :193-203

[2] (-)-FR182877 is a potent and selective inhibitor of carboxylesterase-1 [J].

Adam, GC ;

Vanderwal, CD ;

Sorensen, EJ ;

Cravatt, BF .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (44) :5480-5484

[3] Total synthesis of the microtubule stabilizing antitumor agent laulimalide and some nonnatural analogues:: The power of sharpless' asymmetric epoxidation [J].

Ahmed, A ;

Hoegenauer, EK ;

Enev, VAS ;

Hanbauer, M ;

Kaehlig, H ;

Öhler, E ;

Mulzer, J .

JOURNAL OF ORGANIC CHEMISTRY, 2003, 68 (08) :3026-3042

[4] T-taxol conformation [J].

Alcaraz, AA ;

Mehta, AK ;

Johnson, SA ;

Snyder, JP .

JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (08) :2478-2488

[5] Hydrolyzable hydrophobic taxanes: synthesis and anti-cancer activities [J].

Ali, S ;

Ahmad, I ;

Peters, A ;

Masters, G ;

Minchey, S ;

Janoff, A ;

Mayhew, E .

ANTI-CANCER DRUGS, 2001, 12 (02) :117-128

[6] Epothilones: A novel class of non-taxane microtubule-stabilizing agents [J].

Altaha, R ;

Fojo, T ;

Reed, E ;

Abraham, J .

CURRENT PHARMACEUTICAL DESIGN, 2002, 8 (19) :1707-1712

[7] Epothilone B and its Analogs - A New Family of Anticancer Agents [J].

Altmann, Karl-Heinz .

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2003, 3 (02) :149-158

[8] Recent developments in the chemical biology of epothilones [J].

Altmann, KH .

CURRENT PHARMACEUTICAL DESIGN, 2005, 11 (13) :1595-1613

[9] Epothilones and related structures - a new class of microtubule inhibitors with potent in vivo antitumor activity [J].

Altmann, KH ;

Wartmann, M ;

O'Reilly, T .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2000, 1470 (03) :M79-M91

[10] The merger of natural product synthesis and medicinal chemistry: on the chemistry and chemical biology of epothilones [J].

Altmann, KH .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2004, 2 (15) :2137-2152

← 1 2 3 4 5 6 7 8 9 10 →