Anticancer drugs from nature - natural products as a unique source of new microtubule-stabilizing agents

被引：220

作者：

Altmann, Karl-Heinz ^{[1
]}

Gertsch, Juerg ^{[1
]}

机构：

[1] ETH, Inst Pharmaceut Sci, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland

来源：

NATURAL PRODUCT REPORTS | 2007年 / 24卷 / 02期

关键词：

RING CLOSING METATHESIS; EPOTHILONE-B ANALOG; III BETA-TUBULIN; BIOSYNTHETIC GENE-CLUSTER; MEDIATED ALDOL REACTIONS; HUMAN TUMOR XENOGRAFTS; LARGE-SCALE SYNTHESIS; I CLINICAL-TRIAL; BIOLOGICAL EVALUATION; MARINE SPONGE;

D O I：

10.1039/b515619j

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review article provides an overview on the current state of research in the area of microtubule-stabilizing agents from natural sources, with a primary focus on the biochemistry, biology, and pharmacology associated with these compounds. A variety of natural products have been discovered over the last decade to inhibit human cancer cell proliferation through a taxol-like mechanism. These compounds represent a whole new range of structurally diverse lead structures for anticancer drug discovery.

引用

页码：327 / 357

页数：31

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