Hydroxyapatite whisker-reinforced polyetherketoneketone bone ingrowth scaffolds

被引：100

作者：

Converse, Gabriel L. ^{[1
]}

Conrad, Timothy L. ^{[1
]}

Merrill, Christina H. ^{[1
]}

Roeder, Ryan K. ^{[1
]}

机构：

[1] Univ Notre Dame, Dept Aerosp & Mech Engn, Notre Dame, IN 46556 USA

来源：

ACTA BIOMATERIALIA | 2010年 / 6卷 / 03期

关键词：

Bone ingrowth scaffolds; Composite; Hydroxyapatite; Micro-computed tomography; Polyetheretherketone; BEARING ORTHOPEDIC IMPLANTS; TENSION-TENSION FATIGUE; IN-VITRO; MECHANICAL-PROPERTIES; COMPOSITE SCAFFOLDS; CANCELLOUS BONE; POLYETHERETHERKETONE; FABRICATION; SURFACES; BIOMATERIALS;

D O I：

10.1016/j.actbio.2009.08.004

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Hydroxyapatite (HA) whisker-reinforced polyetherketoneketone (PEKK) bone ingrowth scaffolds were prepared and characterized. High levels of porosity (75-90%) and HA whisker reinforcement (0-40 vol %) were attained using a powder processing approach to mix the HA whiskers, PEKK powder and a NaCl porogen, followed by compression molding at 350-375 degrees C and particle leaching to remove the porogen. The scaffold architecture and microstructure exhibited characteristics known to be favorable for osteointegration. Scaffold porosity was interconnected with a mean pore size in the range 200-300 mu m as measured by micro-computed tomography HA whiskers were embedded within and exposed on the surface of scaffold struts, producing a microscale surface topography, shown by von Kossa staining and scanning electron microscopy Therefore. HA whisker-reinforced PEKK bone ingrowth scaffolds may be advantageous for orthopedic implant fixation, including interbody spinal fusion. (C) 2009 Acta Materialia Inc Published by Elsevier Ltd All rights reserved

引用

页码：856 / 863

页数：8

共 54 条

[1]

Mechanical properties of injection molded hydroxyapatite-polyetheretherketone biocomposites [J].

Abu Bakar, MS ;

Cheang, P ;

Khor, KA .

COMPOSITES SCIENCE AND TECHNOLOGY, 2003, 63 (3-4) :421-425

[2]

Tensile properties, tension-tension fatigue and biological response of polyetheretherketone-hydroxyapatite composites for load-bearing orthopedic implants [J].

Abu Bakar, MS ;

Cheng, MHW ;

Tang, SM ;

Yu, SC ;

Liao, K ;

Tan, CT ;

Khor, KA ;

Cheang, P .

BIOMATERIALS, 2003, 24 (13) :2245-2250

[3]

Agrawal CM, 2001, J BIOMED MATER RES, V55, P141, DOI 10.1002/1097-4636(200105)55:2<141::AID-JBM1000>3.3.CO

[4]

2-A

[5]

*ASTM, 2004, F245004 ASTM

[6]

ASTM, 1999, ASTM Designation, C373-88

[7]

BOBYN JD, 1992, CLIN ORTHOP RELAT R, P79

[8]

Role of material surfaces in regulating bone and cartilage cell response [J].

Boyan, BD ;

Hummert, TW ;

Dean, DD ;

Schwartz, Z .

BIOMATERIALS, 1996, 17 (02) :137-146

[9]

Poly-ε-caprolactone/hydroxyapatite composites for bone regeneration:: in vitro characterization and human osteoblast response [J].

Causa, F ;

Netti, PA ;

Ambrosio, L ;

Ciapetti, G ;

Baldini, N ;

Pagani, S ;

Martini, D ;

Giunti, A .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2006, 76A (01) :151-162

[10]

CHEANG P, 1996, BIOMATERIALS, V17, P534

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