Synthesis and X-ray absorption spectroscopy structural studies of Cu(I) complexes of HistidylHistidine peptides: The predominance of linear 2-coordinate geometry

被引：92

作者：

Himes, Richard A.

Park, Ga Young

Barry, Amanda N.

Blackburn, Ninian J.

Karlin, Kenneth D.

机构：

[1] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA

[2] OHSU, OGI Sch Sci & Engn, Dept Environm & Biomol Syst, Beaverton, OR 97006 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 17期

关键词：

D O I：

10.1021/ja0708013

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Modified His-His dipeptides have been reacted with copper(I) salts to model active-site Cu ions bound by contiguous His residues in certain oxygen-activating copper proteins, as well as amyloid beta-peptide. Chelation of copper(I) by these ligands affords linear, two-coordinate complexes as studied structurally by X-ray absorption spectroscopy. The complexes are robust toward oxidation, showing limited to no reactivity with O-2, and they bind CO weakly. Reaction with a third ligand (N-methylimidazole) affords complexes with a markedly different structure (distorted T-shaped) and reactivity, binding CO and oxidizing rapidly upon exposure to dioxygen.

引用

收藏

页码：5352 / +

页数：3

相关论文

共 36 条

[1] SYNTHESIS, X-RAY CRYSTAL-STRUCTURE, AND MAGNETIC AND SPECTROSCOPIC PROPERTIES OF A NOVEL COPPER(I)-COPPER(II) CLUSTER [J].

AGNUS, Y ;

LOUIS, R ;

WEISS, R .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1980, (18) :867-869

[2] Major changes in copper coordination accompany reduction of peptidylglycine monooxygenase: implications for electron transfer and the catalytic mechanism [J].

Blackburn, NJ ;

Rhames, FC ;

Ralle, M ;

Jaron, S .

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2000, 5 (03) :341-353

[3] X-RAY ABSORPTION-EDGE SPECTROSCOPY OF COPPER(I) COMPLEXES - COORDINATION GEOMETRY OF COPPER(I) IN THE REDUCED FORMS OF COPPER PROTEINS AND THEIR DERIVATIVES WITH CARBON-MONOXIDE [J].

BLACKBURN, NJ ;

STRANGE, RW ;

REEDIJK, J ;

VOLBEDA, A ;

FAROOQ, A ;

KARLIN, KD ;

ZUBIETA, J .

INORGANIC CHEMISTRY, 1989, 28 (07) :1349-1357

[4] BINUCLEAR COMPLEXES .3. SYNTHESIS AND REACTIVITY OF A FAMILY OF COPPER MONOOXYGENASE MODEL SYSTEMS [J].

CASELLA, L ;

GULLOTTI, M ;

PALLANZA, G ;

RIGONI, L .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (13) :4221-4227

[5] Mononuclear and dinuclear copper(I) complexes of bis(3,5-dimethylpyrazol-1-yl)methane: Synthesis, structure, and reactivity [J].

Chou, CC ;

Su, CC ;

Yeh, A .

INORGANIC CHEMISTRY, 2005, 44 (17) :6122-6128

[6] Bis(μ-oxo)dicopper(III) complexes of a homologous series of simple peralkylated 1,2-diamines:: Steric modulation of structure, stability, and reactivity [J].

Cole, AP ;

Mahadevan, V ;

Mirica, LM ;

Ottenwaelder, X ;

Stack, TDP .

INORGANIC CHEMISTRY, 2005, 44 (21) :7345-7364

[7] LEWIS-BASE ADDUCTS OF GROUP-1B METAL(I) COMPOUNDS .12. STRUCTURAL STUDIES OF SOME BIS(METHYL-SUBSTITUTED PYRIDINE)-COPPER(I) AND BIS(METHYL-SUBSTITUTED PYRIDINE)-SILVER(I) NITRATES AND PERCHLORATES [J].

ENGELHARDT, LM ;

PAKAWATCHAI, C ;

WHITE, AH ;

HEALY, PC .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1985, (01) :117-123

[8] The catalytic role of the copper ligand H172 of peptidylglycine α-hydroxylating monooxygenase:: A kinetic study of the H172A mutant [J].

Evans, John P. ;

Blackburn, Ninian J. ;

Klinman, Judith P. .

BIOCHEMISTRY, 2006, 45 (51) :15419-15429

[9] Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis) [J].

Gaggelli, Elena ;

Kozlowski, Henryk ;

Valensin, Daniela ;

Valensin, Gianni .

CHEMICAL REVIEWS, 2006, 106 (06) :1995-2044

[10] USE OF CONDUCTIVITY MEASUREMENTS IN ORGANIC SOLVENTS FOR CHARACTERISATION OF COORDINATION COMPOUNDS [J].

GEARY, WJ .

COORDINATION CHEMISTRY REVIEWS, 1971, 7 (01) :81-&

← 1 2 3 4 →