Combination chemotherapy followed by autologous stem cell transplant for enteropathy-associated T cell lymphoma

被引：49

作者：

Bishton, Mark J. ^{[1
]}

Haynes, Andrew P. ^{[1
]}

机构：

[1] City Hosp Nottingham, Dept Haematol, Nottingham NG5 1PB, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2007年 / 136卷 / 01期

关键词：

bone marrow transplantation; T cell lymphoma;

D O I：

10.1111/j.1365-2141.2006.06371.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Enteropathy-associated T cell lymphoma (EATL) is a rare entity associated with coeliac disease, with a poor prognosis due to perforation and gastrointestinal bleeding during treatment, and a high relapse risk. Six patients were treated with two cycles of IVE (ifosphamide, etoposide, epirubicin), followed by two cycles of high-dose methotrexate (3 g/m(2)) with folinic acid rescue and a BEAM (carmustine, etoposide, cytarabine, melphalan) autograft. Enteral feeding was given throughout treatment. Four patients remain alive in complete remission at 1-83-4-32 years; two have relapsed. Given the historically poor outcome in these patients, this regimen appears very promising in the treatment of EATL.

引用

页码：111 / 113

页数：3

共 12 条

[1] Association of celiac disease and intestinal lymphomas and other cancers [J].

Catassi, C ;

Bearzi, I ;

Holmes, GKT .

GASTROENTEROLOGY, 2005, 128 (04) :S79-S86

[2] Intestinal non-Hodgkin's lymphoma: A multicenter prospective clinical study from the German Study Group on Intestinal non-Hodgkin's Lymphoma [J].

Daum, S ;

Ullrich, R ;

Heise, W ;

Dederke, B ;

Foss, HD ;

Stein, H ;

Thiel, E ;

Zeitz, M ;

Riecken, EO .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (14) :2740-2746

[3] Enteropathy-type intestinal T-cell lymphoma: Clinical features and treatment of 31 patients in a single center [J].

Gale, J ;

Simmonds, PD ;

Mead, GM ;

Sweetenham, JW ;

Wright, DH .

JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (04) :795-803

[4] Enteropathy-associated T-cell lymphoma without a prior diagnosis of coeliac disease:: diagnostic dilemmas and management options [J].

Hönemann, D ;

Prince, HM ;

Hicks, RJ ;

Seymour, JF .

ANNALS OF HEMATOLOGY, 2005, 84 (02) :118-121

[5] Classification of cytotoxic T-Cell and natural killer cell lymphomas [J].

Jaffe, ES ;

Krenacs, L ;

Raffeld, M .

SEMINARS IN HEMATOLOGY, 2003, 40 (03) :175-184

[6] High-dose therapy supported by autologous stem cell transplantation in patients with enteropathy-associated T-cell lymphoma [J].

Jantunen, E ;

Juvonen, E ;

Wiklund, T ;

Putkonen, M ;

Nousiainen, T .

LEUKEMIA & LYMPHOMA, 2003, 44 (12) :2163-2164

[7] Stem cell mobilization in resistant or relapsed lymphoma: superior yield of progenitor cells following a salvage regimen comprising ifosphamide, etoposide and epirubicin compared to intermediate-dose cyclophosphamide [J].

McQuaker, IG ;

Haynes, AP ;

Stainer, C ;

Anderson, S ;

Russell, NH .

BRITISH JOURNAL OF HAEMATOLOGY, 1997, 98 (01) :228-233

[8] Loss of heterozygosity at chromosome 9p2 I is a frequent finding in enteropathy-type T-cell lymphoma [J].

Obermann, EC ;

Diss, TC ;

Hamoudi, RA ;

Munson, P ;

Wilkins, BS ;

Camozzi, MLP ;

Isaacson, PG ;

Du, MQ ;

Dogan, A .

JOURNAL OF PATHOLOGY, 2004, 202 (02) :252-262

[9] CD56 positive intestinal T-cell lymphoma: Treatment with high dose chemotherapy and autologous peripheral blood stem cell transplantation [J].

Okuda, M ;

Nomura, J ;

Tateno, H ;

Kameoka, J ;

Sasaki, T .

INTERNAL MEDICINE, 2002, 41 (09) :734-737

[10] A review of depsipeptide and other histone deacetylase inhibitors in clinical trials [J].

Piekarz, R ;

Bates, S .

CURRENT PHARMACEUTICAL DESIGN, 2004, 10 (19) :2289-2298

← 1 2 →