Cutting Edge: Rapid and Efficient In Vivo Cytotoxicity Cytotoxic T Cells Is Independent of Granzymes A and B

被引：29

作者：

Regner, Matthias ^{[1
]}

Pavlinovic, Lisa

Koskinen, Aulikki

Young, Nicolie

Trapani, Joseph A. ^{[2
]}

Muellbacher, Arno

机构：

[1] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia

[2] Peter MacCallum Canc Ctr, Div Res, Canc Immunol Program, Melbourne, Australia

来源：

JOURNAL OF IMMUNOLOGY | 2009年 / 183卷 / 01期

基金：

英国医学研究理事会;

关键词：

GRANULE-MEDIATED APOPTOSIS; CYTOLYTIC LYMPHOCYTES; TARGET-CELLS; PERFORIN; VIRUS; DEATH; MICE; CTL; LYSIS; LEUKOCYTES;

D O I：

10.4049/jimmunol.0900466

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytotoxic T (Tc) cells lyse target cells via exocytosis of granules containing perforin (perf) and granzymes (gzm). In vitro, gzm delivery into the target cell cytosol results in apoptosis, and in the absence of gzm A and B the induction of apoptosis is severely impaired. However, using in vivo Tc cell killing assays, we find that virus-immune, gzm A x B-deficient (gzmA x B(-/-)) mice are competent to eliminate adoptively transferred target cells pulsed with an immunodominant Tc cell determinant as rapidly and completely as their wild-type counterparts. Specific target cell elimination occurred with similar kinetics in both spleen and lymph nodes. Thus, neither gzmA nor gzmB are required for rapid and efficient in vivo cytotoxicity by Tc cells. The Journal of Immunology, 2009, 183: 37-40.

引用

页码：37 / 40

页数：4

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