The primary cilium: Keeper of the key to cell division

被引：130

作者：

Pan, Junmin ^{[1
]}

Snell, William ^{[2
]}

机构：

[1] Tsinghua Univ, Dept Biol Sci & Technol, Beijing 100084, Peoples R China

[2] Univ Texas Southwestern Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA

来源：

CELL | 2007年 / 129卷 / 07期

关键词：

INTRAFLAGELLAR TRANSPORT; CHLAMYDOMONAS; FLAGELLA; CYCLE;

D O I：

10.1016/j.cell.2007.06.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Assembly of the nonmotile primary cilium of vertebrate cells requires one of the centrioles of the centrosome. A cluster of new studies, including one in this issue of Cell by Pugacheva et al. (2007), reveal that ciliary assembly proteins influence cell-cycle progression and that a centrosomal "mitotic kinase" promotes ciliary disassembly. The link between the cell cycle and the primary cilium may reflect a requirement for liberation of the ciliary centriole to allow the centrosome to form the mitotic spindle.

引用

页码：1255 / 1257

页数：3

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