Environmental enrichment selectively increases 5-HT1A receptor mRNA expression and binding in the rat hippocampus

被引：106

作者：

Rasmuson, S

Olsson, T ^{[1
]}

Henriksson, BG

Kelly, PAT

Holmes, MC

Seckl, JR

Mohammed, AH

机构：

[1] Umea Univ Hosp, Dept Med, S-90185 Umea, Sweden

[2] Umea Univ Hosp, Dept Geriatr, S-90185 Umea, Sweden

[3] Huddinge Hosp, Dept Geriatr, S-14186 Huddinge, Sweden

[4] Western Gen Hosp, Dept Clin Neurosci & Med, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

MOLECULAR BRAIN RESEARCH | 1998年 / 53卷 / 1-2期

基金：

英国惠康基金;

关键词：

5-HT1A receptor; hippocampus; in situ hybridization; environmental enrichment; neuronal plasticity;

D O I：

10.1016/S0169-328X(97)00317-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Environmental enrichment augments neuronal plasticity and cognitive function and possible mediators of these changes are of considerable interest. In this study, male rats were exposed to environmental enrichment or single housing for 30 days. Rats from the enriched group had significantly higher 5-HT1A receptor mRNA expression in the dorsal hippocampus (62%, 59% and 44% increase in the CA1, CA2 and CA3 subfields, respectively). This was associated with significantly higher [H-3]8-OH-DPAT binding in the inferior part of CA1. No changes were seen for 5-HT2A or 5-HT2C receptor mRNAs. The neuronal plasticity detected after environmental change may be mediated, in part, through 5-HT1A receptors. (C) 1998 Elsevier Science B.V.

引用

页码：285 / 290

页数：6

共 37 条

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