High doses of ultraviolet-C irradiation increases vasoactive intestinal contractor/endothelin-2 expression in keratinocytes of the newborn mouse epidermis

被引：5

作者：

Adur, Javier ^{[1
]}

Takizawa, Satoshi

Uchide, Tsuyoshi

Casco, Victor

Saida, Kaname

机构：

[1] Natl Univ Entre Rios, Sch Engn Bioengn, Microscopy Lab, RA-3101 Oro Verde, Entre Rios, Argentina

[2] Natl Inst Adv Ind Sci & Technol, Tsukuba, Ibaraki 3058566, Japan

[3] New Energy & Ind Technol Dev Org, NEDO, Tokyo 1706028, Japan

[4] Kitasato Univ, Sch Vet Med, Toxicol Lab, Towada, Aomori 0348628, Japan

来源：

PEPTIDES | 2007年 / 28卷 / 05期

关键词：

endothelin-2; UVC radiation; gene expression; skin;

D O I：

10.1016/j.peptides.2007.03.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined the expression profiles of vasoactive intestinal contractor/endothelin-2 (VIC/ ET-2) at both gene and peptide level in skin irradiated with different ultraviolet wavelengths. We found that VIC/ET-2 gene expression is sensitive only to ultraviolet-C (UVC) irradiation and has an immediate response. These results provide direct evidence that high doses of UVC irradiation induce an increase in gene expression and protein production of VIC/ET-2 and endothelin (ET) receptors in a dose-dependent manner in epidermal keratinocytes. We suggest that VIC/ET-2 can play an essential role in the maintenance, protection and hyperpigmentation of the epidermis exposed to UVC irradiation from artificial or natural sources. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：1083 / 1094

页数：12

共 64 条

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