Length-dependent uptake of DNA-wrapped single-walled carbon nanotubes

被引：132

作者：

Becker, Matthew L. ^{[1
]}

Fagan, Jeffrey A. ^{[1
]}

Gallant, Nathan D. ^{[1
]}

Bauer, Barry J. ^{[1
]}

Bajpai, Vardan ^{[1
]}

Hobbie, Erik K. ^{[1
]}

Lacerda, Silvia H. ^{[1
]}

Migler, Kalman B. ^{[1
]}

Jakupciak, John P. ^{[1
]}

机构：

[1] Natl Inst Stand & Technol, Polymers Div, Gaithersburg, MD 20899 USA

来源：

ADVANCED MATERIALS | 2007年 / 19卷 / 07期

关键词：

D O I：

10.1002/adma.200602667

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A length threshold for cell uptake of DNA-wrapped single-walled carbon nanotubes (SWNTs) by human lung fibroblasts (IMR90) is identified. Competitive uptake experiments with well-defined and characterized length fractions show that SWNTs above the length threshold are excluded from the cell, whereas SWNTs labeled with Cy3-derivatized DNA below the threshold are able to access the cell interior, as shown in the fluorescence image and on the cover.

引用

页码：939 / +

页数：8

共 38 条

[21] Theory of structure-based carbon nanotube separations by ion-exchange chromatography of DNA/CNT hybrids [J].

Lustig, SR ;

Jagota, A ;

Khripin, C ;

Zheng, M .

JOURNAL OF PHYSICAL CHEMISTRY B, 2005, 109 (07) :2559-2566

[22] Cellular toxicity of carbon-based nanomaterials [J].

Magrez, Arnaud ;

Kasas, Sandor ;

Salicio, Valerie ;

Pasquier, Nathalie ;

Seo, Jin Won ;

Celio, Marco ;

Catsicas, Stefan ;

Schwaller, Beat ;

Forro, Laszlo .

NANO LETTERS, 2006, 6 (06) :1121-1125

[23]

Moghimi SM, 2001, PHARMACOL REV, V53, P283

[24] CHARACTERIZATION OF A NEW HUMAN DIPLOID CELL STRAIN, IMR-90 [J].

NICHOLS, WW ;

MURPHY, DG ;

CRISTOFALO, VJ ;

TOJI, LH ;

GREENE, AE ;

DWIGHT, SA .

SCIENCE, 1977, 196 (4285) :60-63

[25] Chromatographic purification of soluble single-walled carbon nanotubes (s-SWNTs) [J].

Niyogi, S ;

Hu, H ;

Hamon, MA ;

Bhowmik, P ;

Zhao, B ;

Rozenzhak, SM ;

Chen, J ;

Itkis, ME ;

Meier, MS ;

Haddon, RC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (04) :733-734

[26] Selective cell targeting with light-absorbing microparticles and nanoparticles [J].

Pitsillides, CM ;

Joe, EK ;

Wei, XB ;

Anderson, RR ;

Lin, CP .

BIOPHYSICAL JOURNAL, 2003, 84 (06) :4023-4032

[27] Influence of length on cytotoxicity of multi-walled carbon nanotubes against human acute monocytic leukemia cell line THP-I in vitro and subcutaneous tissue of rats in vivo [J].

Sato, Y ;

Yokoyama, A ;

Shibata, K ;

Akimoto, Y ;

Ogino, S ;

Nodasaka, Y ;

Kohgo, T ;

Tamura, K ;

Akasaka, T ;

Uo, M ;

Motomiya, K ;

Jeyadevan, B ;

Ishiguro, M ;

Hatakeyama, R ;

Watari, F ;

Tohji, K .

MOLECULAR BIOSYSTEMS, 2005, 1 (02) :176-182

[28] Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro [J].

Sayes, CM ;

Liang, F ;

Hudson, JL ;

Mendez, J ;

Guo, WH ;

Beach, JM ;

Moore, VC ;

Doyle, CD ;

West, JL ;

Billups, WE ;

Ausman, KD ;

Colvin, VL .

TOXICOLOGY LETTERS, 2006, 161 (02) :135-142

[29] The biocompatibility of carbon nanotubes [J].

Smart, SK ;

Cassady, AI ;

Lu, GQ ;

Martin, DJ .

CARBON, 2006, 44 (06) :1034-1047

[30] An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution [J].

Sun, XK ;

Rossin, R ;

Turner, JL ;

Becker, ML ;

Joralemon, MJ ;

Welch, MJ ;

Wooley, KL .

BIOMACROMOLECULES, 2005, 6 (05) :2541-2554

← 1 2 3 4 →