An organometallic inhibitor for glycogen synthase kinase 3

被引:125
作者
Bregman, H [1 ]
Williams, DS [1 ]
Atilla, GE [1 ]
Carroll, PJ [1 ]
Meggers, E [1 ]
机构
[1] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA
关键词
D O I
10.1021/ja046049c
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Replacing natural products with kinetically inert metal complexes may lead to a new class of therapeutics in which a metal center plays the role of an innocent bystander, organizing the orientation of the organic ligands in the receptor space. As an example of this approach, a ruthenium complex is described that copies the binding mode of indolocarbazole protein kinase inhibitors and serves as a reversible, low-nanomolar inhibitor for glycogen synthase kinase 3 (GSK-3). Copyright © 2004 American Chemical Society.
引用
收藏
页码:13594 / 13595
页数:2
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