An organometallic inhibitor for glycogen synthase kinase 3

被引：125

作者：

Bregman, H ^{[1
]}

Williams, DS ^{[1
]}

Atilla, GE ^{[1
]}

Carroll, PJ ^{[1
]}

Meggers, E ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 42期

关键词：

D O I：

10.1021/ja046049c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Replacing natural products with kinetically inert metal complexes may lead to a new class of therapeutics in which a metal center plays the role of an innocent bystander, organizing the orientation of the organic ligands in the receptor space. As an example of this approach, a ruthenium complex is described that copies the binding mode of indolocarbazole protein kinase inhibitors and serves as a reversible, low-nanomolar inhibitor for glycogen synthase kinase 3 (GSK-3). Copyright © 2004 American Chemical Society.

引用

页码：13594 / 13595

页数：2

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