Potent inhibition of estrogen sulfotransferase by hydroxylated PCB metabolites: A novel pathway explaining the estrogenic activity of PCBs

被引：295

作者：

Kester, MHA ^{[1
]}

Bulduk, S

Tibboel, D

Meinl, W

Glatt, H

Falany, CN

Coughtrie, MWH

Bergman, A

Safe, SH

Kuiper, GGJM

Schuur, AG

Brouwer, A

Visser, TJ

机构：

[1] Erasmus Univ, Sch Med, Dept Internal Med, NL-3015 GE Rotterdam, Netherlands

[2] Erasmus Univ, Sch Med, Dept Pediat Surg, NL-3015 GE Rotterdam, Netherlands

[3] German Inst Human Nutr, Dept Toxicol, D-14558 Potsdam, Germany

[4] Univ Alabama Birmingham, Dept Pharmacol & Toxicol, Birmingham, AL 35294 USA

[5] Univ Dundee, Dept Mol & Cellular Pathol, Dundee DD1 9SY, Scotland

[6] Univ Stockholm, Wallenberg Lab, Dept Environm Chem, S-10691 Stockholm, Sweden

[7] Texas A&M Univ, Dept Vet Physiol & Pharmacol, College Stn, TX 77843 USA

[8] Wageningen Univ Agr, Dept Food Technol & Nutr Sci, Toxicol Grp, NL-6700 EA Wageningen, Netherlands

来源：

ENDOCRINOLOGY | 2000年 / 141卷 / 05期

关键词：

D O I：

10.1210/en.141.5.1897

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Polychlorinated biphenyls (PCBs) are persistent environmental pollutants which exert a variety of toxic effects in animals, including disturbances of sexual development and reproductive function. The estrogenic effects of PCBs may be mediated in part by hydroxylated PCB metabolites (PCB-OHs), but the mechanisms by which they are brought about are not understood. PCBs as well as PCB-OHs show low affinities for both alpha and beta estrogen receptor isoforms. In the present study we demonstrate that various environmentally relevant PCB-OHs are extremely potent inhibitors of human estrogen sulfotransferase, strongly suggesting that they indirectly induce estrogenic activity by increasing estradiol bioavailability in target tissues.

引用

页码：1897 / 1900

页数：4

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