Medical assessment of adverse health outcomes in long-term survivors of childhood cancer

Context Improved survival of children with cancer has been accompanied by multiple treatment-related complications. However, most studies in survivors of childhood cancer focused on only 1 late effect. Objective To assess the total burden of adverse health outcomes ( clinical or subclinical disorders ["adverse events"]) following childhood cancer in a large cohort of childhood cancer survivors with long-term and complete medical follow-up. Design, Setting, and Population Retrospective cohort study of 1362 five-year survivors of childhood cancer treated in a single institution in the Netherlands between 1966 and 1996. All survivors were invited to a late-effects clinic for medical assessment of adverse events. Adverse events occurring before January 2004 were graded for severity in a standardized manner. Main Outcome Measures Treatment-specific prevalence of adverse events ( according to severity) at end of follow-up and relative risk of high or severe burden of disease ( >= 2 severe or >= 1 life-threatening or disabling adverse events) associated with various treatments. Results Medical follow-up was complete for 94.3% of survivors ( median follow-up, 17.0 years). The median attained age at end of follow-up was 24.4 years. Almost 75% of survivors had 1 or more adverse events, and 24.6% had 5 or more adverse events. Furthermore, 40% of survivors had at least 1 severe or life-threatening or disabling adverse event. A high or severe burden of adverse events was observed in 55% of survivors who received radiotherapy only and 15% of survivors treated with chemotherapy only, compared with 25% of survivors who had surgery only ( adjusted relative risks, 2.18 [95% confidence interval, 1.62 - 2.95] and 0.65 [ 95% confidence interval, 0.46 - 0.90], respectively). A high or severe burden of adverse events was most often observed in survivors of bone tumors (64%) and least often in survivors of leukemia or Wilms tumor (12% each). Conclusions In young adulthood, a substantial proportion of childhood cancer survivors already has a high or severe burden of disease, particularly after radiotherapy. This underscores the need for lifelong risk-stratified medical surveillance of childhood cancer survivors.