The Leicester Risk Assessment score for detecting undiagnosed Type 2 diabetes and impaired glucose regulation for use in a multiethnic UK setting

被引:135
作者
Gray, L. J. [1 ]
Taub, N. A. [1 ]
Khunti, K. [1 ]
Gardiner, E. [1 ]
Hiles, S. [2 ]
Webb, D. R. [3 ]
Srinivasan, B. T. [3 ]
Davies, M. J. [3 ]
机构
[1] Univ Leicester, Dept Hlth Sci, Leicester LE1 6TP, Leics, England
[2] Univ Hosp Leicester, Dept Diabet Res, Leicester, Leics, England
[3] Univ Leicester, Dept Cardiovasc Sci, Leicester LE1 6TP, Leics, England
关键词
prevention; risk score; screening; type 2 diabetes mellitus; LIFE-STYLE; GENERAL-PRACTICE; PREVENTION; PREVALENCE; MELLITUS; COMPLICATIONS; DIAGNOSIS; PROGRAM; DISEASE; ADULTS;
D O I
10.1111/j.1464-5491.2010.03037.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
P>Aims Risk assessment scores identify those at high risk of impaired glucose regulation and Type 2 diabetes mellitus. To date no risk assessment scores that can be completed by a lay person have been developed and validated specifically for multiethnic populations in the UK. Methods We used data on 6186 subjects aged 40-75 years from a multiethnic UK screening study (73% white European, 22% South Asian). All participants were given a 75 g oral glucose tolerance test. We developed logistic regression models for predicting current impaired glucose regulation (impaired fasting glycaemia/impaired glucose tolerance) or Type 2 diabetes mellitus using data from anthropometric measurements and self-reported questionnaires. Using the best-fitting model, we developed the Leicester Risk Assessment score. We externally validated the score using data from 3171 subjects aged 40-75 years from a separate screening study. Results The components of the final model are age, ethnicity [white European vs. other (predominantly South Asian)], sex, first degree family history of diabetes, antihypertensive therapy or history of hypertension, waist circumference and body mass index. The score ranges from 0 to 47. Validating this model using the data from the second screening study gave an area under the receiver operator characteristic curve of 72% (95% confidence interval, 69-74%). A cut point of 16 had a sensitivity of 81% and a specificity of 45%. Conclusions The Leicester Risk Assessment score can be used to identify those at high risk of impaired glucose regulation and Type 2 diabetes mellitus in UK multiethnic populations. The score is simple (seven questions) and non-invasive.
引用
收藏
页码:887 / 895
页数:9
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