An evolutionarily conserved splice generates a secreted Env-Bet fusion protein during human foamy virus infection

被引：30

作者：

Giron, ML ^{[1
]}

de Thé, H ^{[1
]}

Saïb, A ^{[1
]}

机构：

[1] Univ Paris 07, Hop St Louis, CNRS UPR 9051, F-75475 Paris 10, France

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 06期

关键词：

D O I：

10.1128/JVI.72.6.4906-4910.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Foamy viruses (spumaretroviruses) represent a retroviral genus which exhibits unusual features relating it to pararetroviruses. Previously, we reported the existence of a protein species harboring Env, Eel, and Bet epitopes in human foamy virus (HFV)-infected cells (M. L. Giron, F. Retain, M. C. Debons-Guillemin, M. Canivet, J. Peries, and R. Emanoil-Ravier, J. Virol, 67:3596-3600, 1993). Here, we identify this protein as a 160-kDa Env-Bet fusion glycoprotein (gp160) translated from an mRNA species harboring a highly conserved splice site which deletes the membrane anchor domain of En, and fuses the env open reading frame with that of bel1/bet. While gp160 and Bet proteins were both secreted into the supernatant, only Bet was taken up by recipient cells, Since Bet plays a key role in the snitch from lytic to chronic infection, secretion of Bet and gp160, together with cellular uptake of Bet, could be highly relevant for both immune response and development of HFV infection in vivo.

引用

页码：4906 / 4910

页数：5

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