Ashkenazi Jewish mtDNA haplogroup distribution varies among distinct subpopulations: lessons of population substructure in a closed group

被引:24
作者
Feder, Jeanette
Ovadia, Ofer
Glaser, Benjamin
Mishmar, Dan [1 ]
机构
[1] Ben Gurion Univ Negev, Dept Life Sci, IL-84105 Beer Sheva, Israel
[2] Hadassah Hebrew Univ, Sch Med, Dept Endocrinol, Jerusalem, Israel
基金
以色列科学基金会;
关键词
ashkenazi jews; population sub-structure; mtDNA;
D O I
10.1038/sj.ejhg.5201764
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The quest for genes associated with diseases is widely recognized as an essential task in the effort to investigate the genetic basis of complex human disorders and traits. A basic stage in association studies is the careful choice of the model population, with preference to closed groups having little population substructure. Here, we show evidence for significant geographic substructure (P = 0.017) of the maternal lineage represented by mitochondrial DNA variation in one of the most commonly studied populations, the Ashkenazi Jews. Most of the substructure effect stems from differential representation of haplogroups K and H. Our results underline the essentiality of adjusting data of population genetic variation for substructure during the design of association studies, even in apparently closed populations.
引用
收藏
页码:498 / 500
页数:3
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