Ca2+-independent phospholipase A2 inhibitor impairs spatial memory of mice

被引：26

作者：

Fujita, S ^{[1
]}

Ikegaya, Y ^{[1
]}

Nishiyama, N ^{[1
]}

Matsuki, N ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Chem Pharmacol Lab, Bunkyo Ku, Tokyo 1130033, Japan

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 2000年 / 83卷 / 03期

关键词：

phospholipase A(2); learning and memory; spontaneous alternation behavior;

D O I：

10.1254/jjp.83.277

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pharmacological blockade of Ca2+-independent phospholipase A(2) (PLA(2)) is reported to disintegrate hippocampal synaptic plasticity, which is thought to be the cellular mechanism underlying learning and memory. Therefore, we investigated the effect of the Ca2+-independent PLA(2) inhibitor bromoenol lactone (BEL) on spontaneous alteration behaviors of mice. When 3 nmol EEL was intracerebroventricularly injected 30 min prior to the test, the mice showed a poor alternation ratio, compared with control animals. The data suggest that Ca2+-independent PLA(2) activity is required for spatial memory.

引用

页码：277 / 278

页数：2

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