Cytokine profile in patients with multiple sclerosis following vitamin D supplementation

被引：220

作者：

Mahon, BD

Gordon, SA

Cruz, J

Cosman, F

Cantorna, MT ^{[1
]}

机构：

[1] Penn State Univ, Grad Program Nutr, University Pk, PA 16802 USA

[2] Helen Hayes Hosp, Clin Res Ctr, W Haverstraw, NY 10993 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2003年 / 134卷 / 1-2期

关键词：

vitamin D; multiple sclerosis; transforming growth factor-beta 1;

D O I：

10.1016/S0165-5728(02)00396-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multiple sclerosis (MS) patients were randomized, in a double blind design, and placed into either a vitamin D supplemented group or a placebo control group. As expected, serum 25-hydroxyvitamin D levels increased significantly following 6 month vitamin D supplementation (17 +/- 6 ng/ml at baseline to 28 +/- 8 ng/ml at 6 months). Vitamin D supplementation also significantly increased serum transforming growth factor (TGF)-beta1 levels from 230 +/- 21 pg/ml at baseline to 295 +/- 40 pg/ml 6 months later. Placebo treatment had no effect on serum TGF-beta1 levels. Tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, and interleukin (IL)-13 were not different following vitamin D supplementation. IL-2 mRNA levels decreased following vitamin D supplementation but the differences did not reach significance. Vitamin D supplementation of MS patients for 6 months was associated with increased vitamin D status and serum TGF-beta1. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：128 / 132

页数：5

共 28 条

[1] Quantitative PCR reveals increased levels of tumor necrosis factor-α mRNA in peripheral blood mononuclear cells of multiple sclerosis patients during relapses [J].