Age-associated changes in the frequency of naive, memory and effector CD8+T cells

被引：69

作者：

Hong, MS ^{[1
]}

Dan, JM ^{[1
]}

Choi, JY ^{[1
]}

Kang, IS ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Rheumatol Sect, New Haven, CT 06520 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2004年 / 125卷 / 09期

关键词：

human; CD8+T lymphocytes; aging; CD45; CCR7;

D O I：

10.1016/j.mad.2004.07.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We investigated age-associated changes in the frequency of CD8+ T cell subsets with different functions. Based on expression of CD45RA and CCRT naive (CD45RA+ CCR7+), central memory (CM, CD45RA- CCR7+), effector memory (EM, CD45RA- CCR7-) and effector (CD45RA+ CCR7-) CD8+ T cells were identified in peripheral blood from healthy young (n = 17) and elderly (n = 17) people using flow cytometry. The elderly had a decreased frequency of naive and an increased frequency of EM and effector CD8+ T cells compared to the young. However, both groups had a similar frequency of CM cells. These findings suggest that age-associated changes in CD8+ T cell subsets occur. which could be a potential explanation for altered CDS+ T cell function in the elderly. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：615 / 618

页数：4

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