Antigens up the nose: Identification of putative biomarkers for nasal tolerance induction functional studies combined with proteomics

被引：5

作者：

Boots, AM

Verhaert, PD

Poele, RJT

Evers, S

Coenen-de Roo, CJ

Cleven, J

Bos, ES

机构：

[1] NV Organon, Dept Target Discovery, NL-5340 BH Oss, Netherlands

[2] NV Organon, Dept Pharmacol, NL-5340 BH Oss, Netherlands

来源：

JOURNAL OF PROTEOME RESEARCH | 2004年 / 3卷 / 05期

关键词：

immunotherapy; mucosa; antigen presentation; nose draining lymph node; haptoglobin; MRP8; nonintegrin 67 kDa laminin receptor; in vivo study; 2D-based proteome analysis;

D O I：

10.1021/pr049907c

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Intranasal autoantigen delivery is the most effective means of inducing mucosal tolerance and suppression of autoimmune disease. In an effort to identify markers of the "tolerant state", we employed proteomics technology at the level of the cervical lymph node. The analysis revealed that nasal antigen administration (without adiuvant) led to modulation of various proteins among which the most prominent were haptoglobin, nonintegrin 67 kDa laminin receptor, and MRP8. The immunoregulatory haptoglobin may qualify as (bio)marker for effective immunotherapy.

引用

页码：1056 / 1062

页数：7

共 39 条

[1] Haptoglobin directly affects T cells and suppresses T helper cell type 2 cytokine release [J].