Synthesis of ceramic-polymer-drug biocomposites at room temperature

被引：12

作者：

Vallet-Regi, M ^{[1
]}

Gordo, M

Ragel, CV

Cabanas, MV

San Roman, J

机构：

[1] Univ Complutense Madrid, Fac Farm, Dept Quim Inorgan & Bioinorgan, E-28040 Madrid, Spain

[2] CSIC, Inst Ciencia & Tecnol Polimeros, E-28006 Madrid, Spain

来源：

SOLID STATE IONICS | 1997年 / 101卷

关键词：

biocomposites; polymerization at room temperature; drug release; ceramic drug complex;

D O I：

10.1016/S0167-2738(97)00219-1

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The preparation of hard composites by the free radical polymerization at room temperature of a blend of beta-tricalcium phosphate, poly(ethyl methacrylate), methyl methacrylate monomer and fosfosal(R) is described. After the immersion of the composites in a buffered solution, the controlled release of an analgesic drug, fosfosal, is observed. The ceramic component participates actively in the control of the release of the drug by means of the formation of a bridging complex with the fosfosal, as demonstrated by FTIR studies.

引用

页码：887 / 892

页数：6

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