A cryptic PKS-NRPS gene locus in the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of an antimitotic rhizoxin complex

被引：50

作者：

Brendel, Nicole

Partida-Martinez, Laila P.

Scherlach, Kirstin

Hertweck, Christian

机构：

[1] HKI, Leibniz Inst Nat Prod Res & Infect Biol, D-07745 Jena, Germany

[2] Univ Jena, D-6900 Jena, Germany

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2007年 / 5卷 / 14期

关键词：

D O I：

10.1039/b707762a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Targeted gene inactivation and metabolic profiling revealed that the cryptic PKS-NRPS gene cluster in the genome of the plant commensal Pseudomonas fluorescens Pf-5 codes for the biosynthesis of antiproliferative and antifungal rhizoxin derivatives.

引用

页码：2211 / 2213

页数：3

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