Hepatoprotective phenolic constituents of Rhodiola sachalinensis on tacrine-induced cytotoxicity in Hep G2 cells

被引：48

作者：

Song, EK

Kim, JH

Kim, JS

Cho, H

Nan, JX

Sohn, DH

Ko, GI

Oh, H

Kim, YC ^{[1
]}

机构：

[1] Wonkwang Univ, Coll Pharm, Iksan 570749, Chonbuk, South Korea

[2] Wonkwang Univ, MRRC, Iksan 570749, South Korea

[3] Wonkwang Univ, Profess Grad Sch Oriental Med, Iksan 570749, South Korea

来源：

PHYTOTHERAPY RESEARCH | 2003年 / 17卷 / 05期

关键词：

Rhodiola sachalinensis; hepatoprotective; tacrine; Hep G2 cells;

D O I：

10.1002/ptr.1166

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two hepatoprotective phenolic compounds, kaempferol (2) and salidroside (4), were isolated from the roots of Rhodiola sachalinensis together with two inactive compounds cinnamyl alcohol (1) and dancosterol (3) based on the hepatoprotective activity against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC50 values of compounds 2 and 4 were 33.5 and 51.3 muM, respectively. Silybin as a positive control showed an EC50 value of 68.4 muM. Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：563 / 565

页数：3

共 14 条

[11] Protective effect of ebselen against hydrogen peroxide-induced cytotoxicity and DNA damage in HepG2 cells [J].