Electrochemical monitoring of piroxicam in different pharmaceutical forms with multi-walled carbon nanotubes paste electrode

被引:75
作者
Abbaspour, Abdolkarim [1 ]
Mirzajani, Roya [1 ]
机构
[1] Shiraz Univ, Dept Chem, Shiraz 71454, Iran
关键词
multi-walled carbon nanotubes; determination; piroxicam; pharmaceutical; carbon paste; voltammetry;
D O I
10.1016/j.jpba.2007.01.027
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The electrochemical behavior of piroxicam on a multi-walled carbon nanotubes electrode for the first time was investigated. A highly sensitive and fast responding sensor for determination of piroxicam was simply and conveniently fabricated. The constructed electrode exhibits efficiently catalytic activity for the electrooxidation of piroxicam at a reduced over potential with high sensitivity, stability, and long lifetime in the wide concentration rang of piroxicam. The oxidation process was found to be dependent on the pH of the supporting electrolyte. The behavior is further exploited as a sensitive detection method for piroxicam determination by differential pulse voltammetry. Under the optimized conditions the calibration plots are linear in the concentration range of 0.15-5 mu g ml(-1). Application of the method for the determination of the drug in the dosage form (Feledene capsules and tablets and also piroxicam gel), without any interference, from the excipients, resulted in acceptable deviation from the stated concentrations. Recoveries were obtained in the range 96.35-104.16%. The detection limit of 0.1 mu g ml(-1) was obtained for piroxicam determination. (c) 2007 Published by Elsevier B.V.
引用
收藏
页码:41 / 48
页数:8
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