Interleukin-18 promoter polymorphisms and risk of ischemic stroke

被引：31

作者：

Zhang, Na ^{[1
]}

Yu, Jin-Tai ^{[1
]}

Yu, Nan-Nan ^{[1
]}

Lu, Rui-Chun ^{[1
]}

Ma, Teng ^{[2
]}

Wang, Nai-Dong ^{[3
]}

Miao, Dan ^{[1
]}

Song, Jing-Hui ^{[3
]}

Tan, Lan ^{[1
]}

机构：

[1] Qingdao Univ, Dept Neurol, Qingdao Municipal Hosp, Sch Med, Qingdao 266071, Shandong, Peoples R China

[2] Qingdao Hiser Hosp, Dept Neurol, Qingdao, Shandong, Peoples R China

[3] Qingdao Univ, Affiliated Hosp, Coll Med, Dept Neurol, Qingdao, Shandong, Peoples R China

来源：

BRAIN RESEARCH BULLETIN | 2010年 / 81卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Ischemic stroke; Inflammation; Interleukin-18; Polymorphisms; HUMAN ATHEROSCLEROTIC PLAQUES; RHEUMATOID-ARTHRITIS PATIENTS; NECROSIS-FACTOR-ALPHA; MYOCARDIAL-INFARCTION; GENE POLYMORPHISMS; CORONARY-ARTERY; ATRIAL-FIBRILLATION; INTERFERON-GAMMA; ASSOCIATION; CYTOKINE;

D O I：

10.1016/j.brainresbull.2010.01.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Ischemic stroke (IS) is a major cause of morbidity and mortality around the world. Interleukin-18 (IL-18) plays an important role in the pathogenesis of IS and IL-18 promoter polymorphisms have been shown to be associated with levels of expression of IL-18. We investigated the association of two functional polymorphisms in IL-18 promoter, -607C/A (rs1946518) and -137G/C (rs187238), with the risk of ischemic stroke in a Han Chinese population of 423 patients and 384 healthy controls matched for sex and age. The results revealed that the -607C allele was associated with an increased risk of IS with an odds ratios (OR) of 1.358 (P = 0.002, power = 100%) and the presence of the -137G allele was correlated with increased the risk of IS in the subtype of patients with large artery atherosclerosis (LAA)(OR = 1.583, P = 0.02, power = 94%). Patients with the -607C/-137G haplotype also had significantly increased risk of IS compared to controls (CR = 1.341, P = 0.005, power = 100%). Our findings suggest that these functional polymorphisms in the IL-18 promoter are involved in development of IS in the Han Chinese population. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：590 / 594

页数：5

共 57 条

[1]

IL-18 gene polymorphisms affect IL-18 production capability by monocytes [J].