Cyclin-dependent kinases: Engines, clocks, and microprocessors

被引：1758

作者：

Morgan, DO ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Biophys, San Francisco, CA 94143 USA

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 1997年 / 13卷

关键词：

cell cycle; cyclin; protein kinase; kinase structure;

D O I：

10.1146/annurev.cellbio.13.1.261

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cyclin-dependent kinases (Cdks) play a well-established role in the regulation of the eukaryotic cell division cycle and have also been implicated in the control of gene transcription and other processes. Cdk activity is governed by a complex network of regulatory subunits and phosphorylation events whose precise effects on Cdk conformation have been revealed by recent crystallographic studies. In the cell, these regulatory mechanisms generate an interlinked series of Cdk oscillators that trigger the events of cell division.

引用

页码：261 / 291

页数：31

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