Initiation of autoimmunity

被引:60
作者
Christen, U [1 ]
von Herrath, MG [1 ]
机构
[1] La Jolla Inst Allergy & Immunol, Dept Dev Immunol, Immune Regulat Lab, San Diego, CA 92121 USA
关键词
D O I
10.1016/j.coi.2004.09.002
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
It has recently become clear that several factors must coincide for the initiation of autoimmunity. At minimum, these involve a genetic predisposition, naive lymphocytes that can react with autoantigens and a precipitating event that leads to T and/or B cell activation. Inter-individual variations in these factors probably explain the significant complexity associated with autoimmune diseases; however, quantitative issues are also important because clinical disease will manifest only if a sufficient amount of cellular material has been destroyed. Therefore, the presence of autoreactive lymphocytes does not always signify disease; rather, the kinetics of their generation, their resulting numbers and the regulation of their activation and effector functions (destructive versus regulatory) will determine the ultimate outcome and make the difference between subclinical autoimmunity and disease.
引用
收藏
页码:759 / 767
页数:9
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