机构:
La Jolla Inst Allergy & Immunol, Dept Dev Immunol, Immune Regulat Lab, San Diego, CA 92121 USALa Jolla Inst Allergy & Immunol, Dept Dev Immunol, Immune Regulat Lab, San Diego, CA 92121 USA
von Herrath, MG
[1
]
机构:
[1] La Jolla Inst Allergy & Immunol, Dept Dev Immunol, Immune Regulat Lab, San Diego, CA 92121 USA
It has recently become clear that several factors must coincide for the initiation of autoimmunity. At minimum, these involve a genetic predisposition, naive lymphocytes that can react with autoantigens and a precipitating event that leads to T and/or B cell activation. Inter-individual variations in these factors probably explain the significant complexity associated with autoimmune diseases; however, quantitative issues are also important because clinical disease will manifest only if a sufficient amount of cellular material has been destroyed. Therefore, the presence of autoreactive lymphocytes does not always signify disease; rather, the kinetics of their generation, their resulting numbers and the regulation of their activation and effector functions (destructive versus regulatory) will determine the ultimate outcome and make the difference between subclinical autoimmunity and disease.
机构:
La Jolla Inst Allergy & Immunol, Dept Dev Immunol, San Diego, CA 92121 USALa Jolla Inst Allergy & Immunol, Dept Dev Immunol, San Diego, CA 92121 USA
机构:
Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA
Devendra, D
;
Eisenbarth, GS
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机构:
Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA
机构:
La Jolla Inst Allergy & Immunol, Dept Dev Immunol, San Diego, CA 92121 USALa Jolla Inst Allergy & Immunol, Dept Dev Immunol, San Diego, CA 92121 USA
机构:
Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA
Devendra, D
;
Eisenbarth, GS
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USAUniv Colorado, Hlth Sci Ctr, Barbara Davis Ctr Childhood Diabet, Denver, CO 80262 USA