Effect of policosanol on platelet aggregation and serum levels of arachidonic acid metabolites in healthy volunteers

被引:60
作者
Carbajal, D [1 ]
Arruzazabala, ML [1 ]
Valdés, S [1 ]
Más, R [1 ]
机构
[1] CNIC, Ctr Nat Prod, Cubanacan Habana, Cuba
来源
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1998年 / 58卷 / 01期
关键词
D O I
10.1016/S0952-3278(98)90130-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Policosanol is a cholesterol-lowering drug with hypocholesterolemic effects demonstrated in experimental models, healthy volunteers and patients with type II hypercholesterolemia. In addition, antiplatelet effects of policosanol have been shown in experimental models and healthy volunteers. This study reports the results of a 2-week, randomized, double-blind, placebo-controlled trial investigating the effects of policosanol on platelet aggregation and thromboxane B-2 and prostacyclin (6 keto PGF(1 alpha)) production after stimulation with collagen in healthy volunteers. The volunteers were on a placebo-baseline period for 7 days and thereafter they received randomly, under double-blind conditions, placebo or policosanol (10 mg/day) for 15 days. Platelet aggregation was determined at baseline and after 15 days of treatment. Significant reductions of arachidonic acid and collagen-induced platelet aggregation were observed. Thromboxane, but not prostacyclin, generation induced by collagen was also inhibited by policosanol.
引用
收藏
页码:61 / 64
页数:4
相关论文
共 27 条
[1]   EFFECT OF POLICOSANOL IN LOWERING CHOLESTEROL LEVELS IN PATIENTS WITH TYPE-II HYPERCHOLESTEROLEMIA [J].
ANEIROS, E ;
MAS, R ;
CALDERON, B ;
ILLNAIT, J ;
FERNANDEZ, L ;
CASTANO, G ;
FERNANDEZ, JC .
CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 1995, 56 (02) :176-182
[2]   EFFECT OF POLICOSANOL ON CEREBRAL-ISCHEMIA IN MONGOLIAN GERBILS - ROLE OF PROSTACYCLIN AND THROMBOXANE A(2) [J].
ARRUZAZABALA, ML ;
MOLINA, V ;
CARBAJAL, D ;
VALDES, S ;
MAS, R .
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1993, 49 (03) :695-697
[3]   EFFECTS OF POLICOSANOL ON PLATELET-AGGREGATION IN RATS [J].
ARRUZAZABALA, ML ;
CARBAJAL, D ;
MAS, R ;
GARCIA, M ;
FRAGA, V .
THROMBOSIS RESEARCH, 1993, 69 (03) :321-327
[4]  
ARRUZAZABALA ML, 1995, 12 INT S DRUG AFF LI
[5]  
ARRUZAZABALA ML, 1992, IBEROAMERICANA TROMB, V5, P17
[6]  
ARRUZAZABALA ML, 1994, BIOL RES, V27, P203
[7]  
ARRUZAZABALA ML, 1996, PHARM RES, V33, P131
[8]  
BAUMGARTNER HR, 1977, THROMB HAEMOSTASIS, V37, P1
[9]   DISTRIBUTION AND METABOLISM OF ARACHIDONIC-ACID IN RABBIT PLATELETS DURING AGGREGATION AND ITS MODIFICATION BY DRUGS [J].
BLACKWELL, GJ ;
DUNCOMBE, WG ;
FLOWER, RJ ;
PARSONS, MF ;
VANE, JR .
BRITISH JOURNAL OF PHARMACOLOGY, 1977, 59 (02) :353-366
[10]   AGGREGATION OF BLOOD PLATELETS BY ADENOSINE DIPHOSPHATE AND ITS REVERSAL [J].
BORN, GVR .
NATURE, 1962, 194 (4832) :927-&