Regulation of the CAMP gene by 1,25(OH)2D3 in various tissues

被引：53

作者：

Gombart, Adrian F. ^{[1
]}

O'Kelly, James ^{[1
]}

Saito, Tsuyako ^{[1
]}

Koeffler, H. Phillip ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Cedars Sinai Med Ctr, Div HematolOncol,Burns & Allen Res Inst, Los Angeles, CA 90048 USA

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2007年 / 103卷 / 3-5期

关键词：

D O I：

10.1016/j.jsbmb.2006.12.095

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The induction of antimicrobial peptides such as the human cathelicidin, CAMP/hCAP18, by 1,25(OH)(2)D-3 provides a very exciting therapeutic approach in boosting immunity against infectious diseases. To explore the range of cell types and expand the number of cell models for studying the regulation of CAMP gene expression by 1,25(OH)(2)D-3, we treated cell lines from various tissue types and determined CAMP gene expression. Also, we tested additional compounds together with 1,25(OH)(2)D-3 to look for possible cooperative activation of the gene. We identified 1,25 (OH)(2)D-3 -mediated induction of the CAMP gene in B-cell lymphomas, prostate and endometrial cancer lines and found cooperative activation with the histone deacetylase inhibitor sodium butyrate. The data suggest that regulation of CAMP by 1,25(OH)(2)D-3 is potentially important in a wide range of tissues. (c) 2007 Published by Elsevier Ltd.

引用

页码：552 / 557

页数：6

共 39 条

[1] Pharmacological induction of tolerogenic dendritic cells and regulatory T cells [J].