Marine n-3 polyunsaturated fatty acids and coronary heart disease - Part I. Background, epidemiology, animal data, effects on risk factors and safety

被引:94
作者
Schmidt, EB [1 ]
Arnesen, H
de Caterina, R
Rasmussen, LH
Kristensen, SD
机构
[1] Arhus Univ Hosp, Aalborg Sygehus, Dept Prevent Cardiol, Aarhus, Denmark
[2] Ullevaal Univ Hosp, Dept Cardiol, Oslo, Norway
[3] Univ G dAnnunzio, Inst Cardiol, Chieti, Italy
[4] Univ G dAnnunzio, Ctr Excellence Aging, Chieti, Italy
[5] Skejby Univ Hosp, Dept Cardiol, Skejby, Denmark
关键词
polyunsaturated fatty acids; fish consumption; coronary heart disease;
D O I
10.1016/j.thromres.2004.09.006
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In this paper, we will give an overview of the background for the possible effects of long-chain marine n-3 (synonomously called omega-3) polyunsaturated fatty acids (PUFA) in coronary heart disease (CND) with focus on recent findings. In a forthcoming paper [Schmidt EB, Arnesen H, Christensen JH, Rasmussen LH, Kristensen SD, De Caterina R, Marine n-3 polyunsaturated fatty acids and coronary heart disease: Part II. Clinical trials and recommendations. Thromb Res (in press)], we will focus on the clinical trial data, current recommendations and suggest trials to further study the role of marine n-3 PUFA in the prevention and treatment of CHD. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:163 / 170
页数:8
相关论文
共 73 条
[1]   Blood levels of long-chain n-3 fatty acids and the risk of sudden death. [J].
Albert, CM ;
Campos, H ;
Stampfer, MJ ;
Ridker, PM ;
Manson, JE ;
Willett, WC ;
Ma, J .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (15) :1113-1118
[2]   Fish consumption and risk of sudden cardiac death [J].
Albert, CM ;
Hennekens, CH ;
O'Donnell, CJ ;
Ajani, UA ;
Carey, VJ ;
Willett, WC ;
Ruskin, JN ;
Manson, JE .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 279 (01) :23-28
[3]   Effect of dietary supplementation with ω-3 fatty acids on progression of atherosclerosis in carotid arteries [J].
Angerer, P ;
Kothny, W ;
Störk, S ;
von Schacky, C .
CARDIOVASCULAR RESEARCH, 2002, 54 (01) :183-190
[4]   DIETARY-INTAKE OF MARINE N-3 FATTY-ACIDS, FISH INTAKE, AND THE RISK OF CORONARY-DISEASE AMONG MEN [J].
ASCHERIO, A ;
RIMM, EB ;
STAMPFER, MJ ;
GIOVANNUCCI, EL ;
WILLETT, WC .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (15) :977-982
[5]   Effects of marine fish oils on the anticoagulation status of patients receiving chronic warfarin therapy [J].
Bender, NK ;
Kraynak, MA ;
Chiquette, E ;
Linn, WD ;
Clark, GM ;
Bussey, HI .
JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 1998, 5 (03) :257-261
[6]   Prevention of sudden cardiac death by dietary pure ω-3 polyunsaturated fatty acids in dogs [J].
Billman, GE ;
Kang, JX ;
Leaf, A .
CIRCULATION, 1999, 99 (18) :2452-2457
[7]   Peroxidation of LDL from combined-hyperlipidemic male smokers supplied with (omega)over-bar-3 fatty acids and antioxidants [J].
Brude, IR ;
Drevon, CA ;
Hjermann, I ;
Seljeflot, I ;
LundKatz, S ;
Saarem, K ;
Sandstad, B ;
Solvoll, K ;
Halvorsen, B ;
Arnesen, H ;
Nenseter, MS .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (11) :2576-2588
[8]  
Christensen JH, 2003, DAN MED BULL, V50, P347
[9]   Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) [J].
Cleeman, JI ;
Grundy, SM ;
Becker, D ;
Clark, LT ;
Cooper, RS ;
Denke, MA ;
Howard, WJ ;
Hunninghake, DB ;
Illingworth, DR ;
Luepker, RV ;
McBride, P ;
McKenney, JM ;
Pasternak, RC ;
Stone, NJ ;
Van Horn, L ;
Brewer, HB ;
Ernst, ND ;
Gordon, D ;
Levy, D ;
Rifkind, B ;
Rossouw, JE ;
Savage, P ;
Haffner, SM ;
Orloff, DG ;
Proschan, MA ;
Schwartz, JS ;
Sempos, CT ;
Shero, ST ;
Murray, EZ .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (19) :2486-2497
[10]   Fish consumption is associated with lower heart rates [J].
Dallongeville, J ;
Yarnell, J ;
Ducimetière, P ;
Arveiler, D ;
Ferrières, J ;
Montaye, M ;
Luc, G ;
Evans, A ;
Bingham, A ;
Hass, B ;
Ruidavets, JB ;
Amouyel, P .
CIRCULATION, 2003, 108 (07) :820-825