Comparative genomics of major histocompatibility complexes

被引:335
作者
Kelley, J
Walter, L
Trowsdale, J
机构
[1] Univ Cambridge, Dept Pathol, Div Immunol, Cambridge CB2 1QP, England
[2] German Primate Ctr, Dept Primate Genet, Gottingen, Germany
基金
英国医学研究理事会;
关键词
D O I
10.1007/s00251-004-0717-7
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The major histocompatibility complex (MHC) is a gene dense region found in all jawed vertebrates examined to date. The MHC contains a high percentage of immune genes, in particular genes involved in antigen presentation, which are generally highly polymorphic. The region plays an important role in disease resistance. The clustering of MHC genes could be advantageous for co-evolution or regulation, and its study in many species is desirable. Even though some linkage of MHC genes is apparent in all gnathostomes, the genomic organization can differ greatly by species, suggesting rapid evolution of MHC genes after divergence from a common ancestor. Previous reviews of comparative MHC organization have been written when relatively fragmentary sequence and mapping data were available on many species. This review compares maps of MHC gene orders in commonly studied species, where extensive sequencing has been performed.
引用
收藏
页码:683 / 695
页数:13
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