Quinone-enhanced ascorbate reduction of nitric oxide: Role of quinone redox potential

被引：15

作者：

Alegria, AE ^{[1
]}

Sanchez, S ^{[1
]}

Quintana, I ^{[1
]}

机构：

[1] Univ Puerto Rico, Dept Chem, CUH Stn, Humacao, PR 00791 USA

来源：

FREE RADICAL RESEARCH | 2004年 / 38卷 / 10期

关键词：

quinones; 1,4-naphthoquinone; nitric oxide; methyl-1,4-naphthoquinone; trimethyl-1,4-benzoquinone; 2,3-dimethoxy-5-methal-1,4-benzoquinone;

D O I：

10.1080/10715760400009852

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The quinones 1,4-naphthoquinone (NQ), methyl-1,4-naphthoquinone (MNQ), trimethyl-1,4-benzoquinone (TMQ) and 2,3-dimethoxy-5-methyl-1,4-benzoquinone (UQ-0) enhance the rate of nitric oxide (NO) reduction by ascorbate in nitrogen-saturated phosphate buffer (pH 7.4). The observed rate constants for this reaction were determined to be 16+/-2,215+/-6,290+/-14 and 462+/-18 M-1 s(-1) , for MNQ, TMQ, NQ and UQ-0, respectively. These rate constants increase with an increase in quinone one-electron redox potential at neutral pH, E-7(1) . Since NO production is enhanced under hypoxia and under certain pathological conditions, the observations obtained in this work are very relevant to such conditions.

引用

页码：1107 / 1112

页数：6

共 50 条

[1] Role of membrane charge and semiquinone structure on oxygen consumption rates [J].

Alegría, AE ;

Rivera, L ;

Cordones, E ;

Castro, V ;

Sanchez-Cruz, P .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 2002, (11) :1823-1828

[2] Reductive activation of terpenylnaphthoquinones [J].

Alegria, AE ;

Cordones, E ;

Santiago, G ;

Marcano, Y ;

Sanchez, S ;

Gordaliza, M ;

Martín-Martín, ML .

TOXICOLOGY, 2002, 175 (1-3) :167-175

[3] PREPARATION OF P-BENZOQUINONES [J].

ANSELL, MF ;

WILSON, DA ;

NASH, BW .

JOURNAL OF THE CHEMICAL SOCIETY, 1963, (MAY) :3028-&

[4] The reduction potential of nitric oxide (NO) and its importance to NO biochemistry [J].

Bartberger, MD ;

Liu, W ;

Ford, E ;

Miranda, KM ;

Switzer, C ;

Fukuto, JM ;

Farmer, PJ ;

Wink, DA ;

Houk, KN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (17) :10958-10963

[5] Solubility of nitrous oxide in amine solutions [J].

Bensetiti, Z ;

Iliuta, I ;

Larachi, F ;

Grandjean, BPA .

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 1999, 38 (01) :328-332

[6] Quinoids, quinoid radicals, and phenoxyl radicals formed from estrogens and antiestrogens [J].

Bolton, JL .

TOXICOLOGY, 2002, 177 (01) :55-65

[7] IN THE ABSENCE OF CATALYTIC METALS ASCORBATE DOES NOT AUTOXIDIZE AT PH-7 - ASCORBATE AS A TEST FOR CATALYTIC METALS [J].

BUETTNER, GR .

JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, 1988, 16 (01) :27-40

[8] THE PECKING ORDER OF FREE-RADICALS AND ANTIOXIDANTS - LIPID-PEROXIDATION, ALPHA-TOCOPHEROL, AND ASCORBATE [J].

BUETTNER, GR .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1993, 300 (02) :535-543

[9] Nitric oxide in systemic and pulmonary hypertension [J].

Chen, HI ;

Hu, CT ;

Wu, CY ;

Wang, D .

JOURNAL OF BIOMEDICAL SCIENCE, 1997, 4 (05) :244-248

[10] 2ND MESSENGER ROLE FOR NO WIDENS TO NERVOUS AND IMMUNE-SYSTEMS [J].

COLLIER, J ;

VALLANCE, P .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1989, 10 (11) :427-431

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