Quinone-enhanced ascorbate reduction of nitric oxide: Role of quinone redox potential

被引：15

作者：

Alegria, AE ^{[1
]}

Sanchez, S ^{[1
]}

Quintana, I ^{[1
]}

机构：

[1] Univ Puerto Rico, Dept Chem, CUH Stn, Humacao, PR 00791 USA

来源：

FREE RADICAL RESEARCH | 2004年 / 38卷 / 10期

关键词：

quinones; 1,4-naphthoquinone; nitric oxide; methyl-1,4-naphthoquinone; trimethyl-1,4-benzoquinone; 2,3-dimethoxy-5-methal-1,4-benzoquinone;

D O I：

10.1080/10715760400009852

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The quinones 1,4-naphthoquinone (NQ), methyl-1,4-naphthoquinone (MNQ), trimethyl-1,4-benzoquinone (TMQ) and 2,3-dimethoxy-5-methyl-1,4-benzoquinone (UQ-0) enhance the rate of nitric oxide (NO) reduction by ascorbate in nitrogen-saturated phosphate buffer (pH 7.4). The observed rate constants for this reaction were determined to be 16+/-2,215+/-6,290+/-14 and 462+/-18 M-1 s(-1) , for MNQ, TMQ, NQ and UQ-0, respectively. These rate constants increase with an increase in quinone one-electron redox potential at neutral pH, E-7(1) . Since NO production is enhanced under hypoxia and under certain pathological conditions, the observations obtained in this work are very relevant to such conditions.

引用

页码：1107 / 1112

页数：6

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