From worm to human: bioinformatics approaches to identify FOXO tarcyet genes

被引:48
作者
Xuan, ZY [1 ]
Zhang, MQ [1 ]
机构
[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
关键词
Foxo target genes; insulin pathway; comparative genomics; aging;
D O I
10.1016/j.mad.2004.09.021
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Longevity regulatory genes include the Forkhead transcription factor FOXO, in addition to NAD-dependent histone deacetylase silent information regulator 2 (Sir2). The FOXO/DAF-16 family of transcription factors constitute an evolutionarily conserved subgroup within a larger family known as winged helix or Forkhead transcriptional regulators. Here we demonstrate how to identify, FOXO target genes and their potential cis-regulatory binding sites in the promoters via bioinformatics approaches. These results provide new testable hypotheses for further experimental verifications. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:209 / 215
页数:7
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