Inert site in a protein zinc cluster: Isotope exchange by high resolution mass spectrometry

被引：30

作者：

Blindauer, CA

Polfer, NC

Keiper, SE

Harrison, MD

Robinson, NJ

Langridge-Smith, PRR

Sadler, PJ

机构：

[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 2JJ, Midlothian, Scotland

[2] Univ Newcastle Upon Tyne, Dept Biosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 11期

关键词：

D O I：

10.1021/ja0284409

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Using electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry, we show that one Zn2+ ion in the Zn4 cluster of cyanobacterial metallothionein is inert to exchange with 67Zn2+. We suggest that this is zinc in site A, which together with the surrounding α and β secondary structure forms a zinc-finger fold. Copyright © 2003 American Chemical Society.

引用

页码：3226 / 3227

页数：2

共 27 条

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